Bretazenil

Bretazenil
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay28411-1 1 mg -

6 - 10 business days*

50.00€
Cay28411-5 5 mg -

6 - 10 business days*

131.00€
Cay28411-10 10 mg -

6 - 10 business days*

191.00€
Cay28411-25 25 mg -

6 - 10 business days*

415.00€
 
Bretazenil is a positive allosteric modulator of GABAA receptors with anticonvulsant and... more
Product information "Bretazenil"
Bretazenil is a positive allosteric modulator of GABAA receptors with anticonvulsant and anxiolytic activity. It potentiates GABA-gated chloride currents in rat cortical neurons and in HEK293 cells expressing alpha1beta1gamma2 subunit-containing GABAA receptors (EC50s = 60 and 10 nM, respectively). Bretazenil inhibits binding of the benzodiazepine diazepam to rat cerebral cortex homogenates (IC50 = 2.2 nM). It inhibits tonic convulsions induced by pentylenetetrazol (PTZ, Cay-18682) and maximal electroshock (MES) in rats (ED50s = 0.07 and 0.48 mg/kg, respectively). Bretazenil (5-30 mg/kg) increases the number of open arm entries and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.Formal Name: 8-bromo-11,12,13,13aS-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 1,1-dimethylethyl ester. CAS Number: 84379-13-5. Synonyms: Ro 16-6028. Molecular Formula: C19H20BrN3O3. Formula Weight: 418.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): Partially soluble. lambdamax: 217 nm. SMILES: BrC1=CC=CC(N2C([C@@]3([H])N4CCC3)=C(C(OC(C)(C)C)=O)N=C2)=C1C4=O. InChi Code: InChI=1S/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3/t13-/m0/s1. InChi Key: LWUDDYHYYNNIQI-ZDUSSCGKSA-N.
Keywords: Ro 16-6028, (13aS)-8-bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 1,1-dimethylethyl ester
Supplier: Cayman Chemical
Supplier-Nr: 28411

Properties

Application: GABA-A receptor positive allosteric modulator
MW: 418.3 D
Formula: C19H20BrN3O3
Purity: >98%
Format: Solid

Database Information

CAS : 84379-13-5| Matching products
KEGG ID : K05181 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Bretazenil"
Write a review
or to review a product.
Viewed