BRD6989

Item number	Size	Delivery time	Price
TGM-T14778-1mg	1 mg	7 - 10 business days*	31.00€
TGM-T14778-5mg	5 mg	7 - 10 business days*	67.00€
TGM-T14778-1mL	1 ml	7 - 10 business days*	77.00€
TGM-T14778-10mg	10 mg	7 - 10 business days*	98.00€
TGM-T14778-25mg	25 mg	7 - 10 business days*	206.00€
TGM-T14778-50mg	50 mg	7 - 10 business days*	367.00€
TGM-T14778-100mg	100 mg	7 - 10 business days*	549.00€

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Description: BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8... more

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Product information "BRD6989"

Description: BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. Target: IL Receptor, CDK, Interleukin. Smiles: CC1CCc2nc(N)c(C#N)c(-c3cccnc3)c2C1. References: Johannessen L, et al. Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat Chem Biol. 2017 Oct,13(10):1102-1108

Supplier:	TargetMol
Supplier-Nr:	T14778

Properties

Application:	Cdk8/cyclin C complex inhibitor
MW:	264.33 D
Formula:	C16H16N4

Database Information

CAS :	642008-81-9\| Matching products
KEGG ID :	K02208 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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