BRD3308

BRD3308 is an inhibitor of histone deacetylase 3 (HDAC3, Ki = 29 nM). It is selective for HDAC3 over HDAC1 and HDAC2 (Kis = 6,300 and 5,100 nM, respectively). BRD3308 (10 µM) reduces cytokine-induced increases in apoptosis in rat INS-1E beta cells. In vivo, BRD3308 (5 mg/kg) reduces plasma glucose levels in rats and increases plasma insulin levels in rats in a hyperglycemic clamp assay as a model of type 2 diabetes.Formal Name: 4-(acetylamino)-N-(2-amino-4-fluorophenyl)-benzamide. CAS Number: 1550053-02-5. Molecular Formula: C15H14FN3O2. Formula Weight: 287.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 243, 286, 303 nm. SMILES: O=C(C1=CC=C(NC(C)=O)C=C1)NC2=CC=C(C=C2N)F. InChi Code: InChI=1S/C15H14FN3O2/c1-9(20)18-12-5-2-10(3-6-12)15(21)19-14-7-4-11(16)8-13(14)17/h2-8H,17H2,1H3,(H,18,20)(H,19,21). InChi Key: RRJDFENBXIEAPD-UHFFFAOYSA-N.