BQR-695

BQR-695 is an antimalarial compound. It inhibits recombinant P. vivax and human phosphatidylinositol 4-kinase (PI4K, IC50s = 3.5 and 90 nM, respectively). BQR-695 induces schizont-stage arrest and death of P. falciparum (IC50 = ~70 nM) without inducing cytotoxicity in mature red blood cells (RBCs).Formal Name: 2-[[7-(3,4-dimethoxyphenyl)-2-quinoxalinyl]amino]-N-methyl-acetamide. CAS Number: 1513879-21-4. Molecular Formula: C19H20N4O3. Formula Weight: 352.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: COC1=C(OC)C=CC(C2=CC=C(N=CC(NCC(NC)=O)=N3)C3=C2)=C1. InChi Code: InChI=1S/C19H20N4O3/c1-20-19(24)11-22-18-10-21-14-6-4-12(8-15(14)23-18)13-5-7-16(25-2)17(9-13)26-3/h4-10H,11H2,1-3H3,(H,20,24)(H,22,23). InChi Key: LYPCULYCGFOIDA-UHFFFAOYSA-N.