BPN14770

BPN14770 is an inhibitor of phosphodiesterase 4D (PDE4D). It selectively inhibits dimeric PDE4DS129D and PDE4DS54D, which mimic the phosphorylated, activated forms of PDE4D, over wild-type dimeric PDE4D, dimeric PDE4DS133D, and monomeric PDE4D2 (IC50s = 7.8, 7.4, 1,018, 2,013, and 127 nM, respectively). BPN14770 (0.3-30 mg/kg) enhances novel object discrimination in mice. It decreases hyperarousal and increases social interaction time, indicating anxiolytic-like activity, nesting, and marble-burying behavior in the Fmr1-/- mouse model of fragile X syndrome when administered at a dose of 0.3 mg/kg.Formal Name: 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-benzeneacetic acid. CAS Number: 1606974-33-7. Synonyms: Zatolmilast. Molecular Formula: C21H15ClF3NO2. Formula Weight: 405.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: O=C(CC1=CC=C(CC2=CC(C(F)(F)F)=NC(C3=CC(Cl)=CC=C3)=C2)C=C1)O. InChi Code: InChI=1S/C21H15ClF3NO2/c22-17-3-1-2-16(12-17)18-9-15(10-19(26-18)21(23,24)25)8-13-4-6-14(7-5-13)11-20(27)28/h1-7,9-10,12H,8,11H2,(H,27,28). InChi Key: LTSUMTMGJHPGFX-UHFFFAOYSA-N.