BMY 7378

BMY 7378 is an antagonist of the alpha2C-adrenoceptor and alpha1D-adrenoceptor with pKi values of 6.54 and 8.2, respectively, that has been used in functional systems to assess the contribution of these receptors in vascular smooth muscle contraction. It also acts as a partial agonist at the serotonin 5-HT1A receptor with a pKi value of 8.3.Formal Name: 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione, dihydrochloride. CAS Number: 21102-95-4. Molecular Formula: C22H31N3O3 . 2HCl. Formula Weight: 458.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 25 mg/ml, Ethanol: 0.2 mg/ml, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 208, 240, 279 nm. SMILES: COC1=CC=CC=C1N2CCN(CCN3C(CC4(CCCC4)CC3=O)=O)CC2.Cl.Cl. InChi Code: InChI=1S/C22H31N3O3.2ClH/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22,,/h2-3,6-7H,4-5,8-17H2,1H3,2*1H. InChi Key: NIBOMXUDFLRHRV-UHFFFAOYSA-N.