BMS 986188

BMS 986188 is a positive allosteric modulator of delta-opioid receptors, with an EC50 value of 0.05 µM in a beta-arrestin recruitment assay in the presence, but not absence, of the opioid receptor agonist leu-enkephalin (Cay-23283). It is selective for delta- over µ-opioid receptors (EC50 = >10 µM) in the presence of leu-enkephalin and the µ-opioid receptor agonist endomorphin 1 (Cay-23280), respectively.Formal Name: 9-[4-[(2-bromophenyl)methoxy]phenyl]-3,4,5,6,7,9-hexahydro-3,3,6,6-tetramethyl-1H-xanthene-1,8(2H)-dione. CAS Number: 1776115-10-6. Molecular Formula: C30H31BrO4. Formula Weight: 535.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1mg/mL, DMF:PBS (pH 7.2) (1:2): 0.3mg/mL, DMSO: slightly soluble, Ethanol: slightly soluble. lambdamax: 223, 286 nm. SMILES: BrC1=C(COC2=CC=C(C3C(C(CC(C)(C)C4)=O)=C4OC(CC(C)(C)C5)=C3C5=O)C=C2)C=CC=C1. InChi Code: InChI=1S/C30H31BrO4/c1-29(2)13-22(32)27-24(15-29)35-25-16-30(3,4)14-23(33)28(25)26(27)18-9-11-20(12-10-18)34-17-19-7-5-6-8-21(19)31/h5-12,26H,13-17H2,1-4H3. InChi Key: BBCHHZHONQIODT-UHFFFAOYSA-N.