BMS 299897
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: BMS 299897 is a sulfonamide gamma-secretase inhibitor with an IC50 of 7 nM for... more
Product information "BMS 299897"
Description: BMS 299897 is a sulfonamide gamma-secretase inhibitor with an IC50 of 7 nM for inhibiting Abeta production in HEK293 cells stably overexpressing amyloid precursor protein (APP). Target: Gamma-secretase, Beta Amyloid. Smiles: C[C@@H](N(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1)c1ccc(F)cc1CCCC(O)=O. References: Meunier J, et al. The gamma-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Abeta1-42 seeding and short-term memory deficits in the Abeta25-35 mouse model of Alzheimer's disease. Eur J Pharmacol. 2013,698(1-3):193-199.
| Supplier: | TargetMol |
| Supplier-Nr: | T14673 |
Properties
| Application: | Gamma-secretase inhibitor |
| MW: | 511.94 D |
| Formula: | C24H21ClF3NO4S |
Database Information
| CAS : | 290315-45-6| Matching products |
| KEGG ID : | K04520 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H319 |
| P Phrases: | P264, P270, P280, P301+310, P305+351+338, P330, P337+313, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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