BML-278

BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 µM. It less potently activates SIRT2 and SIRT3 (EC150s = 25 and 50 µM, respectively). BML-278 induces hypoacetylation on alpha-tubulin in U937 cells that are pretreated with SAHA (Cay-10009929), a histone deacetylase inhibitor. It arrests cell cycling at the G1/S phase, reduces senescence in primary human mesenchymal cells, and significantly increases mitochondrial density in murine C2C12 myoblasts.Formal Name: 1,4-dihydro-4-phenyl-1-(phenylmethyl)-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester. CAS Number: 120533-76-8. Molecular Formula: C24H25NO4. Formula Weight: 391.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12.5 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 3 mg/ml. lambdamax: 226, 368 nm. SMILES: O=C(OCC)C1=CN(CC2=CC=CC=C2)C=C(C(OCC)=O)C1C3=CC=CC=C3. InChi Code: InChI=1S/C24H25NO4/c1-3-28-23(26)20-16-25(15-18-11-7-5-8-12-18)17-21(24(27)29-4-2)22(20)19-13-9-6-10-14-19/h5-14,16-17,22H,3-4,15H2,1-2H3. InChi Key: JOHFECBOWRGWJZ-UHFFFAOYSA-N.