BL 1249

BL 1249 is an activator of mechanosensitive two-pore domain potassium channels (K2P). It selectively induces currents in Xenopus oocytes expressing K2P2.1/TREK-1 or K2P10.1/TREK-2 over Xenopus oocytes expressing K2P4.1/TRAAK, K2P3.1/TASK1, K2P3.2/TASK2, K2P3.3/TASK3, K2P18.1/TRESK, K2P13.1/THIK1, or K2P1.1/TWIK-1 at 10 µM.Formal Name: 5,6,7,8-tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine. CAS Number: 18200-13-0. Molecular Formula: C17H17N5. Formula Weight: 291.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, DMSO: Sparingly soluble: 1-10 mg/ml, Methanol: Slightly soluble: 0.1-1 mg/ml. SMILES: C1(C2=C(NC3=CC=CC4=C3CCCC4)C=CC=C2)=NN=NN1. InChi Code: InChI=1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22). InChi Key: YYNRZIFBTOUICE-UHFFFAOYSA-N.