(+)-Biotin 4-Amidobenzoic Acid (sodium salt)

(+)-Biotin 4-amidobenzoic acid is a biotinidase substrate. Upon enzymatic hydrolysis, 4-aminobenzoic acid (PABA, Cay-18659) is released which can be quantified by colorimetric detection at 540 nm in the presence of N-1-naphthylethylenediamine as a measure of biotinidase activity. (+)-Biotin 4-amidobenzoic acid has been used in the evaluation of biotinidase deficiency, an inborn error of metabolism characterized by ketolactic acidosis, hyperammonemia, and neurological dysfunction.Formal Name: 4-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-benzoic acid, monosodium salt. CAS Number: 102418-74-6. Synonyms: (+)-Biotin PABA, N-Biotinyl-4-aminobenzoic Acid. Molecular Formula: C17H20N3O4S . Na. Formula Weight: 385.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/mL, PBS (pH 7.2): 1 mg/mL. lambdamax: 262 nm. SMILES: [O-]C(C1=CC=C(NC(CCCC[C@@H]2SC[C@@]3([H])[C@]2([H])NC(N3)=O)=O)C=C1)=O.[Na+]. InChi Code: InChI=1S/C17H21N3O4S.Na/c21-14(18-11-7-5-10(6-8-11)16(22)23)4-2-1-3-13-15-12(9-25-13)19-17(24)20-15,/h5-8,12-13,15H,1-4,9H2,(H,18,21)(H,22,23)(H2,19,20,24),/q,+1/p-1/t12-,13-,15-,/m0./s1. InChi Key: AMXZKFYBAOWERX-HZPCBCDKSA-M.