Bimosiamose

Bimosiamose
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay30878-1 1 mg -

6 - 10 business days*

114.00€
Cay30878-5 5 mg -

6 - 10 business days*

417.00€
 
Bimosiamose is a pan-selectin inhibitor (IC50s = 88, 20, and 86 µM for E-, P-, and L-selectin,... more
Product information "Bimosiamose"
Bimosiamose is a pan-selectin inhibitor (IC50s = 88, 20, and 86 µM for E-, P-, and L-selectin, respectively). It reduces adhesion of HL-60 cells to E- and P-selectin when used at a concentration of 129 µM. In vivo, bimosiamose (200 mg/kg) reduces skin scaliness, induration, and erythema in a patient-derived xenograft mouse model of psoriasis. It decreases hepatic alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and myeloperoxidase (MPO) levels and reduces neutrophil infiltration in a rat model of severe hepatic ischemia-reperfusion injury. Bimosiamose also prevents nematode-induced late airway reactivity in sheep and reduces airway hyperresponsiveness in a mouse model of asthma.Formal Name: 3',3'''-(1,6-hexanediyl)bis[6'-(alpha-D-mannopyranosyloxy)-[1,1'-biphenyl]-3-acetic acid. CAS Number: 187269-40-5. Synonyms: TBC 1269. Molecular Formula: C46H54O16. Formula Weight: 862.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. SMILES: OC(CC1=CC=CC(C2=C(O[C@@H]3[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C=CC(CCCCCCC4=CC(C5=CC=CC(CC(O)=O)=C5)=C(O[C@@H]6[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)C=C4)=C2)=C1)=O. InChi Code: InChI=1S/C46H54O16/c47-23-35-39(53)41(55)43(57)45(61-35)59-33-15-13-25(19-31(33)29-11-5-9-27(17-29)21-37(49)50)7-3-1-2-4-8-26-14-16-34(60-46-44(58)42(56)40(54)36(24-48)62-46)32(20-26)30-12-6-10-28(18-30)22-38(51)52/h5-6,9-20,35-36,39-48,53-58H,1-4,7-8,21-24H2,(H,49,50)(H,51,52)/t35-,36-,39-,40-,41+,42+,43+,44+,45+,46+/m1/s1. InChi Key: RYWCQJDEHXJHRI-XJMXIVSISA-N.
Keywords: TBC 1269, 3',3'''-(1,6-hexanediyl)bis[6'-(alpha-D-mannopyranosyloxy)-[1,1'-biphenyl]-3-acetic acid
Supplier: Cayman Chemical
Supplier-Nr: 30878

Properties

Application: pan Selectin inhibitor
MW: 862.9 D
Formula: C46H54O16
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 187269-40-5| Matching products
KEGG ID : K06544 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335
P Phrases: P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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