Bifonazole

Description: Bifonazole (Bay H-4502) acts to destabilize the fungal cytochrome p450 51 enzyme (also known as Lanosterol 14-alpha-demethylase). It works by inhibiting the production of a substance called ergosterol, which is an essential component of fungal cell membranes. This is vital in the cell membrane structure of the fungus. Its inhibition leads to cell lysis. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. Target: Antibiotic, Antifungal, P450. Smiles: C(C1=CC=C(C=C1)C2=CC=CC=C2)(N3C=CN=C3)C4=CC=CC=C4. References: Zhao Y, et al. J Biol Chem,2006, 281(9), 5973-5981.