Bictegravir (sodium salt)

Bictegravir is an inhibitor of HIV-1 integrase (IC50 = 7.5 nM for strand transfer activity). It has antiviral activity against clinical isolates of HIV-1 in human peripheral blood mononuclear cells (PBMCs, EC50s = 0.04-1.7 nM). Bictegravir also inhibits HIV-1 viral infection in MT-2 and MT-4 cells, CD4+ T cells, and macrophages (EC50s = 1.5, 2.5, 1.5, and 6.6 nM, respectively) without exhibiting cytotoxicity (CC50s = 10.3, 3.7, 13, and 29.8 µM, respectively). Formulations containing bictegravir in combination with emtricitabine and tenofovir alafenamide have been used in the treatment of HIV-1 infections.Formal Name: 2,3,4,5,7,9,13,13a-octahydro-8-hydroxy-7,9-dioxo-N-[(2,4,6-trifluorophenyl)methyl]-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide, monosodium salt. CAS Number: 1807988-02-8. Synonyms: GS-9883. Molecular Formula: C21H17F3N3O5 . Na. Formula Weight: 471.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: O=C1N2[C@@](O[C@H]3C[C@@H]2CC3)([H])CN4C1=C(C(C(C(NCC5=C(C=C(C=C5F)F)F)=O)=C4)=O)[O-].[Na+]. InChi Code: InChI=1S/C21H18F3N3O5.Na/c22-9-3-14(23)12(15(24)4-9)6-25-20(30)13-7-26-8-16-27(10-1-2-11(5-10)32-16)21(31)17(26)19(29)18(13)28,/h3-4,7,10-11,16,29H,1-2,5-6,8H2,(H,25,30),/q,+1/p-1/t10-,11+,16+,/m0./s1. InChi Key: WJNFBIVCQMPPJC-FQYDJHLKSA-M.