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Bicalutamide is a non-steroidal androgen receptor antagonist that binds the androgen receptor (Ki = 12.5 µM, IC50 = 1.2 µM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones. Bicalutamide is frequently used to examine the role of androgen receptor inactivation in the proliferation of prostate cancer cells and has served as a molecular template for the design and structural optimization of more selective androgen receptor modulators for androgen therapy.Formal Name: N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-propanamide. CAS Number: 90357-06-5. Synonyms: ICI 176334, ZD 176334. Molecular Formula: C18H14F4N2O4S. Formula Weight: 430.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml, DMSO: 14 mg/ml, Ethanol: 1 mg/ml. lambdamax: 215, 271 nm. SMILES: OC(CS(C1=CC=C(F)C=C1)(=O)=O)(C)C(NC2=CC(C(F)(F)F)=C(C#N)C=C2)=O. InChi Code: InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25). InChi Key: LKJPYSCBVHEWIU-UHFFFAOYSA-N.
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