BI-99179

BI-99179 is an inhibitor of fatty acid synthase type I (FAS-I, IC50 = 79 nM), a multifunctional enzyme that catalyzes the conversion of acetyl-coenzyme A (acetyl-CoA, Cay-16160) and malonyl-CoA (Cay-16455) to long-chain fatty acids. It is selective for FAS-I over 30 other enzymes, receptors, and ion channels at 10 µM. BI-99179 inhibits the incorporation of 14C-acetate in mouse N-42 hypothalamus cells (IC50 = 570 nM). It reduces the proliferation of GaMG human glioma cells when used at a concentration of 10 µM.Formal Name: N-[4-(2-benzoxazolyl)phenyl]-N-methyl-3S-[(1R-oxopropyl)amino]-cyclopentanecarboxamide. CAS Number: 1291779-76-4. Molecular Formula: C23H25N3O3. Formula Weight: 391.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml, DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: CN(C([C@@H]1CC[C@H](NC(CC)=O)C1)=O)C2=CC=C(C3=NC4=CC=CC=C4O3)C=C2. InChi Code: InChI=1S/C23H25N3O3/c1-3-21(27)24-17-11-8-16(14-17)23(28)26(2)18-12-9-15(10-13-18)22-25-19-6-4-5-7-20(19)29-22/h4-7,9-10,12-13,16-17H,3,8,11,14H2,1-2H3,(H,24,27)/t16-,17+/m1/s1. InChi Key: YNFDIGJKJPNFFD-SJORKVTESA-N.