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BI-605906 is an inhibitor of inhibitor of kappa B kinase subunit beta (IKKbeta, IC50 = 380 nM). It is selective for IKKbeta over insulin-like growth factor 1 (IGF1, IC50 = 7.6 µM) and over 100 kinases in a panel up to 10 µM. BI-605906 partially inhibits IL-1-stimulated activation of IKKepsilon/TBK1 in vitro. BI-605906 also inhibits TNF-alpha-dependent IkB degradation and expression of the proinflammatory cytokines IL-6, IL-1beta, and C-X-C motif ligand 1/2 (CXCL1/2) without affecting lipogenic gene expression or glucose production in murine primary hepatocytes.Formal Name: 3-amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]-thieno[2,3-b]pyridine-2-carboxamide. CAS Number: 960293-88-3. Molecular Formula: C17H22F2N4O3S2. Formula Weight: 432.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Acetonitrile: 1 mg/ml, DMSO: 30 mg/ml. lambdamax: 244, 306, 347, 360 nm. SMILES: NC1=C(C(N)=O)SC2=NC(N3CCC(S(C)(=O)=O)CC3)=CC(C(F)(F)CC)=C21. InChi Code: InChI=1S/C17H22F2N4O3S2/c1-3-17(18,19)10-8-11(23-6-4-9(5-7-23)28(2,25)26)22-16-12(10)13(20)14(27-16)15(21)24/h8-9H,3-7,20H2,1-2H3,(H2,21,24). InChi Key: IYHHRZBKXXKDDY-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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