Bexarotene-d4

Bexarotene-d4 is intended for use as an internal standard for the quantification of bexarotene (Cay-11571) by GC- or LC-MS. Bexarotene is a high-affinity ligand for retinoid X receptors (RXRs) (EC50s = 28, 25, and 20 nM for RXRalpha, beta, and gamma, respectively). It inhibits cell cycle progression, induces apoptosis, prevents or overcomes multidrug resistance through multidrug resistance protein 1 (MDR1), and blocks angiogenesis and metastasis, making it a promising chemopreventive agent against cancer. Bexarotene also, through RXR activation, stimulates clearance of soluble beta-amyloid, reduces plaque area, and reverses deficits related to Alzheimer's disease in mice.Formal Name: 4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]-benzoic acid-d4. CAS Number: 2182068-00-2. Molecular Formula: C24H24D4O2. Formula Weight: 352.5. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 260 nm. SMILES: C=C(C1=C([2H])C([2H])=C(C(O)=O)C([2H])=C1[2H])C2=CC3=C(C=C2C)C(C)(C)CCC3(C)C. InChi Code: InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)/i7D,8D,9D,10D. InChi Key: NAVMQTYZDKMPEU-ULDPCNCHSA-N.