beta-Glucuronidase Inhibitor

beta-Glucuronidase inhibitor is an inhibitor of bacterial beta-glucuronidase (IC50 = 283 nM for the E. coli enzyme). It inhibits wild-type but not Delta360-376 E. coli beta-glucuronidase, a mutant lacking the bacteria-specific loop, when used at a concentration of 100 µM. In vivo, beta-glucuronidase inhibitor (50 mg/kg) reduces colonic epithelial damage and the number of bloody diarrheal events induced by irinotecan (CPT-11) in a mouse model of chemotherapy-induced intestinal toxicity.Formal Name: N-[(1,2-dihydro-6,8-dimethyl-2-oxo-3-quinolinyl)methyl]-N'-(4-ethoxyphenyl)-N-(2-hydroxyethyl-thiourea. CAS Number: 484006-66-8. Molecular Formula: C23H27N3O3S. Formula Weight: 425.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: O=C1NC2=C(C=C1CN(CCO)C(NC3=CC=C(C=C3)OCC)=S)C=C(C)C=C2C. InChi Code: InChI=1S/C23H27N3O3S/c1-4-29-20-7-5-19(6-8-20)24-23(30)26(9-10-27)14-18-13-17-12-15(2)11-16(3)21(17)25-22(18)28/h5-8,11-13,27H,4,9-10,14H2,1-3H3,(H,24,30)(H,25,28). InChi Key: PSKUPWXOVUAUJD-UHFFFAOYSA-N.