beta-Carboline-1-carboxylic Acid

beta-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-alpha, IL-6, and IL-1beta levels in RAW 264.7 cells when used at a concentration of 15 µg/ml and inhibits the epithelial-to-mesenchymal transition (EMT) induced by TGF-beta1 in A549 cells. beta-Carboline-1-carboxylic acid induces cytotoxicity in CT26.WT, K562, and SGC-7901 cells (IC50s = 14.96, 22.11, and 19.7 µg/ml, respectively) but not HepG2 or A549 cells (IC50s = 36.41 and 41.51 µg/ml, respectively). It also inhibits cAMP phosphodiesterase with an IC50 value of 96 µM.Formal Name: 9H-pyrido[3,4-b]indole-1-carboxylic acid. CAS Number: 26052-96-0. Synonyms: 1-Formic Acid-beta-carboline. Molecular Formula: C12H8N2O2. Formula Weight: 212.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: O=C(C1=NC=CC2=C1NC3=C2C=CC=C3)O. InChi Code: InChI=1S/C12H8N2O2/c15-12(16)11-10-8(5-6-13-11)7-3-1-2-4-9(7)14-10/h1-6,14H,(H,15,16). InChi Key: VNPNEGORDFERGK-UHFFFAOYSA-N. Origin: Plant/Quassia amara.