Bepridil (hydrochloride)

Bepridil is a dihydropyridine that has anti-anginal and anti-arrhythmic actions by blocking calcium channels in heart and smooth muscle. It is recognized as a non-selective channel blocker, altering myocardial Ca2+, Na+, and K+ currents. For example, it blocks voltage-gated Ca2+ (Cav3.2) and K+ (hERG and KCNQ4) channels, sarcoplasmic ATP-sensitive K+ (KATP) channels, and Na+-activated (KNa) channels (IC50s = 7.1, 22, 9.4, 10, and 2.2 µM, respectively). It also activates mitochondrial ATP-sensitive KATP channels (ED50 = 27.5 µM).Formal Name: beta-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethanamine, monohydrochloride. CAS Number: 68099-86-5. Molecular Formula: C24H34N2O . HCl. Formula Weight: 403.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/mL, DMSO: 5 mg/mL, Ethanol: 25 mg/mL, Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/mL. lambdamax: 248, 295 nm. SMILES: CC(C)COCC(N1CCCC1)CN(CC2=CC=CC=C2)C3=CC=CC=C3.Cl. InChi Code: InChI=1S/C24H34N2O.ClH/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22,/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3,1H. InChi Key: JXBBWYGMTNAYNM-UHFFFAOYSA-N.