Benzamil (hydrochloride)

Benzamil is a derivative of amiloride (Cay-14409). Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles. It is also an inhibitor of the Na+/Ca2+ exchanger (NCX) that inhibits the cytosolic calcium response to extracellular sodium depletion in mouse podocytes (IC50 = ~100 nM). Benzamil inhibits transient receptor potential polycystin-L (TRPP3, IC50 = 1.1 µM), a member of the TRP superfamily of cation channels.Formal Name: 3,5-diamino-6-chloro-N-[imino[(phenylmethyl)amino]methyl]-2-pyrazinecarboxamide, monohydrochloride. CAS Number: 161804-20-2. Molecular Formula: C13H14ClN7O . HCl. Formula Weight: 356.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.5 mg/ml, DMSO: 20 mg/ml. lambdamax: 210, 288, 363 nm. SMILES: ClC1=C(N)N=C(N)C(C(NC(NCC2=CC=CC=C2)=N)=O)=N1.Cl. InChi Code: InChI=1S/C13H14ClN7O.ClH/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7,/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22),1H. InChi Key: ZNWMRWWNJBXNKJ-UHFFFAOYSA-N.