Benserazide

Description: Benserazide is an inhibitor of dopa decarboxylase. It is often given with levodopa in the treatment of Parkinson's to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. Target: Others. Smiles: C(NNC(C(CO)N)=O)C1=C(O)C(O)=C(O)C=C1. References: Wan Y, Wu N, Song L, Wang X, Liu Z, Yuan W, Gan J. Levodopa/Benserazide Loaded Microspheres Alleviate L-dopa Induced Dyskinesia through Preventing the Over-Expression of D1R/Shp-2/ERK1/2 Signaling Pathway in a Rat Model of Parkinson's Disease. Front Aging Neurosci. 2017 Oct 18,9:331. doi: 10.3389/fnagi.2017.00331. eCollection 2017. PubMed PMID: 29093677, PubMed Central PMCID: PMC5651254.