Benazepril-d5 (hydrochloride)

Benazepril-d5 is intended for use as an internal standard for the quantification of benazepril (Cay-23804). Benazepril is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat (Cay-21796). It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity of partially purified ACE isolated from rabbit lung (IC50 = 2 nM). It decreases the triglyceride and total cholesterol levels in normotensive rats when administered at a dose of 30 mg/kg and decreases aortic atherosclerosis in cholesterol-fed rabbits when administered at a dose of 3 mg/kg per day. Benazepril (0.1-10 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats. It also decreases proteinuria in cats with chronic kidney disease when administered at doses ranging from 0.5 to 1 mg/kg per day. Formulations containing benazepril have been used to treat hypertension, congestive heart failure, and chronic kidney disease in both human and veterinary medicine.Formal Name: 2-((S)-3-(((S)-1-ethoxy-1-oxo-4-(phenyl-d5)butan-2-yl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid, monohydrochloride. CAS Number: 1279026-26-4. Synonyms: CGS 14824A-d5. Molecular Formula: C24H23D5N2O5 . HCl. Formula Weight: 466.0. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Ethanol: slightly soluble, Methanol: slightly soluble. SMILES: O=C(OCC)[C@@H](N[C@H]1CCC2=C(C=CC=C2)N(CC(O)=O)C1=O)CCC3=C([2H])C([2H])=C([2H])C([2H])=C3[2H].Cl. InChi Code: InChI=1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28,/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28),1H/t19-,20-,/m0./s1/i3D,4D,5D,8D,9D,. InChi Key: VPSRQEHTHIMDQM-KFAZQMGHSA-N.