BBT594

Item number	Size	Manual	Delivery time	Price
SYN-1225-M001	1 mg	-	3 - 9 business days*	250.00€
SYN-1225-M005	5 mg	-	3 - 9 business days*	514.00€
SYN-1225-M010	10 mg	-	3 - 9 business days*	856.00€
SYN-1225-M050	50 mg	-	3 - 9 business days*	-
SYN-1225-M100	100 mg	-	3 - 9 business days*	-

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BBT594 (NVP-BBT594) is a potent and selective inhibitor of RET and JAK2. BBT594 impairs... more

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Product information "BBT594"

BBT594 (NVP-BBT594) is a potent and selective inhibitor of RET and JAK2. BBT594 impairs "glial-derived neurotrophic factor" (GDNF)-RET signaling and GDNF-dependent growth in specific in vitro models. Direct inhibition of GDNF-RET signaling by BBT594 in ER+ breast cancer cells enhances the sensitivity to aromatase inhibitor (AI) treatment and reverts AI resistance. In murine models, the IC50 of BBT594 on JAK2 inhibition varies between 8nM - 29nM, depending on the cell model and abundant JAK2 mutations.

Keywords:	BBT-594
Supplier:	SYNkinase
Supplier-Nr:	1225

Properties

Application:	Potent, selective RET / JAK2 inhibitor
MW:	569.6 D
Formula:	C28H30F3N7O3
Purity:	>95%
Format:	Solid

Database Information

CAS :	882405-89-2\| Matching products
KEGG ID :	K05126 \| Matching products

Handling & Safety

Storage:	+4°C
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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