BAY-826

BAY-826 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2, IC50 = 0.5 nM). It inhibits Tie2 autophosphorylation in human umbilical vein endothelial cells (HUVECs, EC50 = 1.3 nM). BAY-826 (0.1 or 1 µM), in combination with radiation, reduces colony formation in a colony formation assay using SMA-497, SMA-540, SMA-560, and GL261 mouse glioma cells. In vivo, BAY 826 (100 mg/kg per day), in combination with radiation, decreases tumor volume and vascularization, as well as increases the number of CD45+ T cell tumor infiltrates and animal survival in an SMA-560 murine glioma model.Formal Name: [3-cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluoro-sulfur. CAS Number: 1448316-08-2. Synonyms: BAY-Tie2, BAY-Tunica Interna Endothelial Cell Kinase 2. Molecular Formula: C26H19F5N6OS. Formula Weight: 558.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml, DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: CC1=C(C=C(N2C=CN3N=C(C4=CC=CN=C4)C=C32)C(C)=C1)NC(C5=CC(S(F)(F)(F)(F)F)=CC(C#N)=C5)=O. InChi Code: InChI=1S/C26H19F5N6OS/c1-16-8-17(2)24(36-6-7-37-25(36)13-23(35-37)19-4-3-5-33-15-19)12-22(16)34-26(38)20-9-18(14-32)10-21(11-20)39(27,28,29,30)31/h3-13,15H,1-2H3,(H,34,38). InChi Key: MPASHPJAIUOWCK-UHFFFAOYSA-N.