BAY-8002

BAY-8002 is an inhibitor of monocarboxylate transporter 1 (MCT1, IC50 = 11.4 nM). It inhibits lactate uptake in DLD-1 cells expressing human MCT1 (IC50 = 85 nM) but not Evsa-T cells expressing human MCT4 (IC50 = >50 µM). It inhibits the proliferation of 24 cancer cell lines when used at a concentration of 10 µM. BAY-8002 (50 and 100 mg/kg) reduces intratumor lactate levels and tumor area in a Raji mouse xenograft model.Formal Name: 2-[[2-chloro-5-(phenylsulfonyl)benzoyl]amino]-benzoic acid. CAS Number: 724440-27-1. Molecular Formula: C20H14ClNO5S. Formula Weight: 415.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 10 mg/ml. lambdamax: 214, 244 nm. SMILES: O=C(C1=C(NC(C2=CC(S(=O)(C3=CC=CC=C3)=O)=CC=C2Cl)=O)C=CC=C1)O. InChi Code: InChI=1S/C20H14ClNO5S/c21-17-11-10-14(28(26,27)13-6-2-1-3-7-13)12-16(17)19(23)22-18-9-5-4-8-15(18)20(24)25/h1-12H,(H,22,23)(H,24,25). InChi Key: CLAUJSRBKSRTGQ-UHFFFAOYSA-N.