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BAY-4931 is a PPARgamma inverse agonist. It acts as an inverse agonist in a co-repressor reporter assay with a peptide from nuclear receptor co-repressor 2 (NCOR2, EC50 = 5.8 nM). BAY-4931 is selective for PPARgamma in reporter assays using CHO cells (IC50s = 0.14 and 0.4 nM for the mouse and human receptors, respectively) over PPARalpha and PPARdelta in reporter assays using CHO cells (IC50s = >50 µM for both human receptors). BAY-4931 inhibits the proliferation of UM-UC-9 human bladder cancer cells that endogenously contain a focal amplification of PPARG, the gene encoding PPARgamma (IC50 = 3.4 nM).Formal Name: 2-chloro-N-[2-(4-ethylphenyl)-5-benzoxazolyl]-5-nitro-benzamide. CAS Number: 423150-91-8. Molecular Formula: C22H16ClN3O4. Formula Weight: 421.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml. SMILES: ClC1=CC=C(C=C1C(NC2=CC=C3OC(C4=CC=C(CC)C=C4)=NC3=C2)=O)[N+]([O-])=O. InChi Code: InChI=1S/C22H16ClN3O4/c1-2-13-3-5-14(6-4-13)22-25-19-11-15(7-10-20(19)30-22)24-21(27)17-12-16(26(28)29)8-9-18(17)23/h3-12H,2H2,1H3,(H,24,27). InChi Key: WFEBALYYDASKIV-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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