BAY-4931

BAY-4931 is a PPARgamma inverse agonist. It acts as an inverse agonist in a co-repressor reporter assay with a peptide from nuclear receptor co-repressor 2 (NCOR2, EC50 = 5.8 nM). BAY-4931 is selective for PPARgamma in reporter assays using CHO cells (IC50s = 0.14 and 0.4 nM for the mouse and human receptors, respectively) over PPARalpha and PPARdelta in reporter assays using CHO cells (IC50s = >50 µM for both human receptors). BAY-4931 inhibits the proliferation of UM-UC-9 human bladder cancer cells that endogenously contain a focal amplification of PPARG, the gene encoding PPARgamma (IC50 = 3.4 nM).Formal Name: 2-chloro-N-[2-(4-ethylphenyl)-5-benzoxazolyl]-5-nitro-benzamide. CAS Number: 423150-91-8. Molecular Formula: C22H16ClN3O4. Formula Weight: 421.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml. SMILES: ClC1=CC=C(C=C1C(NC2=CC=C3OC(C4=CC=C(CC)C=C4)=NC3=C2)=O)[N+]([O-])=O. InChi Code: InChI=1S/C22H16ClN3O4/c1-2-13-3-5-14(6-4-13)22-25-19-11-15(7-10-20(19)30-22)24-21(27)17-12-16(26(28)29)8-9-18(17)23/h3-12H,2H2,1H3,(H,24,27). InChi Key: WFEBALYYDASKIV-UHFFFAOYSA-N.