BAY-1895344

BAY-1895344 is an inhibitor of ataxia-telangiectasia and Rad3-related protein/kinase (ATR, IC50 = 0.007 µM). It is selective for ATR over DNA protein kinase (DNA-PK), ataxia-telangiectasia mutated kinase (ATM), and PI3Kbeta (IC50s = 0.332, 1.42, and 3.27 µM, respectively). BAY-1895344 inhibits proliferation of HT-29 and LoVo colorectal cancer cells and SU-DHL-8 B lymphoma cells with IC50 values of 0.16, 0.071, and 0.009 µM, respectively. It reduces tumor growth in a mutant ATMK1964E-containing SU-DHL-8 mouse xenograft model when administered at a dose of 50 mg/kg. BAY-1895344 is synergistic with carboplatin (Cay-13112), olaparib (Cay-10621), or radiation in various mouse xenograft models.Formal Name: 2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridine. CAS Number: 1876467-74-1. Synonyms: Elimusertib. Molecular Formula: C20H21N7O. Formula Weight: 375.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 1 mg/ml. lambdamax: 221, 282 nm. SMILES: CN1C(C2=CC(N3[C@@H](COCC3)C)=NC4=C2C=CN=C4C5=NNC=C5)=CC=N1. InChi Code: InChI=1S/C20H21N7O/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6-21-20(19(14)24-18)16-4-7-22-25-16/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25)/t13-/m1/s1. InChi Key: YBXRSCXGRPSTMW-CYBMUJFWSA-N.