Bavachin

Bavachin is a flavonoid first isolated from seeds of P. corylifolia. It is a phytoestrogen that activates the estrogen receptors ERalpha and ERbeta (EC50s = 320 and 680 nM, respectively). Through this action, bavachin stimulates osteoblast proliferation and differentiation and prevents bone loss following ovariectomy in rats. Bavachin less potently inhibits acyl-coenzyme A:cholesterol acyltransferase (IC50 = 86 µM).Formal Name: (2S)-2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one. CAS Number: 19879-32-4. Synonyms: Corylifolin. Molecular Formula: C20H20O4. Formula Weight: 324.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/mL, DMF:PBS (pH 7.2)(1:3): 0.25 mg/mL, DMSO: 30 mg/mL, Ethanol: 20 mg/mL. lambdamax: 221, 236, 278, 322 nm. SMILES: OC1=CC(O[C@H](C2=CC=C(O)C=C2)CC3=O)=C3C=C1C/C=C(C)/C. InChi Code: InChI=1S/C20H20O4/c1-12(2)3-4-14-9-16-18(23)11-19(24-20(16)10-17(14)22)13-5-7-15(21)8-6-13/h3,5-10,19,21-22H,4,11H2,1-2H3/t19-/m0/s1. InChi Key: OAUREGNZECGNQS-IBGZPJMESA-N. Origin: Plant/Psoralea corylifolia.