BAR502

BAR502 is a dual agonist of the G protein-coupled bile acid-activated receptor and farnesoid x receptor (GP-BAR1 and FXR, EC50s = 0.2 and 1 µM, respectively). It increases the expression of the FXR-regulated bile salt export pump (BSEP), organic solute transporter alpha (OSTalpha), and small heterodimer partner (SHP) in primary hepatocytes isolated from FXR wild-type mice. BAR502 also increases cAMP-luciferase reporter gene expression, a marker of GP-BAR1 activity, in HEK293T cells.Formal Name: (3alpha,5beta,6alpha,7alpha)-6-ethyl-24-norcholane-3,7,23-triol. CAS Number: 1612191-86-2. Molecular Formula: C25H44O3. Formula Weight: 392.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/mL, DMSO: 100µg/ml, Ethanol: 2 mg/mL, Ethanol:PBS (pH 7.2)(1:2): 500µg/ml. SMILES: C[C@H](CCO)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C. InChi Code: InChI=1S/C25H44O3/c1-5-17-21-14-16(27)8-11-25(21,4)20-9-12-24(3)18(15(2)10-13-26)6-7-19(24)22(20)23(17)28/h15-23,26-28H,5-14H2,1-4H3/t15-,16-,17-,18-,19+,20+,21+,22+,23-,24-,25-/m1/s1. InChi Key: HYCMOIGNYNCMRH-APIYUPOTSA-N.