BAN ORL 24 (hydrochloride)

BAN ORL 24 is an antagonist of the nociceptin (NOP) receptor (Ki = 0.24 nM in a radioligand binding assay using CHO cell membranes expressing the human receptor). It is selective for NOP receptors over µ-, delta-, and kappa-opioid receptors (Kis = 0.19, 0.34, and >1 µM, respectively). BAN ORL 24 reduces NOP-induced GTPgammaS binding (pA2 = 9.98) and calcium mobilization (KB = 0.93 nM) in CHO cells. It inhibits electrically induced twitches in isolated mouse and rat vas deferens, as well as isolated guinea pig ileum, when used at a concentration of 100 nM. BAN ORL 24 (10 mg/kg) reverses thermal and mechanical antinociceptive activities induced by the dual agonist of µ-opioid and NOP receptors BPR1M97 in mice.Formal Name: 1-(phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl)propyl]-2-pyrrolidinecarboxamide, dihydrochloride. CAS Number: 1401463-54-4. Molecular Formula: C27H35N3O2 . 2HCl. Formula Weight: 506.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Water: Soluble. SMILES: O=C([C@@H]1N(CC2=CC=CC=C2)CCC1)NCCCN3CCC4(OCC5=CC=CC=C54)CC3.Cl.Cl. InChi Code: InChI=1S/C27H35N3O2.2ClH/c31-26(25-12-6-17-30(25)20-22-8-2-1-3-9-22)28-15-7-16-29-18-13-27(14-19-29)24-11-5-4-10-23(24)21-32-27,,/h1-5,8-11,25H,6-7,12-21H2,(H,28,31),2*1H/t25-,,/m1../s1. InChi Key: NEEVITHVDIQNJY-KHZPMNTOSA-N.