Balicatib

Balicatib is a potent inhibitor of cathepsin K (IC50s = 1.4, 56, and 480 nM for human, rat, and mouse forms, respectively). it is at least 100-fold selective for cathepsin K over cathepsins B, L, and S. Balicatib has a basic lipophilic nature, resulting in lysosomal trapping and increased selectivity for lysosomal cathepsin K.Formal Name: N-[1-[[(cyanomethyl)amino]carbonyl]cyclohexyl]-4-(4-propyl-1-piperazinyl)-benzamide. CAS Number: 354813-19-7. Synonyms: AAE581. Molecular Formula: C23H33N5O2. Formula Weight: 411.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 202, 297 nm. SMILES: CCCN1CCN(C2=CC=C(C(NC3(C(NCC#N)=O)CCCCC3)=O)C=C2)CC1. InChi Code: InChI=1S/C23H33N5O2/c1-2-14-27-15-17-28(18-16-27)20-8-6-19(7-9-20)21(29)26-23(10-4-3-5-11-23)22(30)25-13-12-24/h6-9H,2-5,10-11,13-18H2,1H3,(H,25,30)(H,26,29). InChi Key: LLCRBOWRJOUJAE-UHFFFAOYSA-N.