Baicalein

Baicalein is a flavonoid originally isolated from the roots of S. baicalensis that has diverse biological activities. It inhibits human platelet 12-lipoxygenase (12-LO) and human reticulocyte 15-LO-1 (IC50s = 0.64 and 1.6 µM, respectively) but is less potent at 15-LO-1 when the detergent Triton-X is present (IC50 = 38 µM). Baicalein inhibits lipid peroxidation, as assessed by production of thiobarbituric acid (TBARS, IC50 = 5 µM), and inhibits growth of Huh-7, KIM-1, and HLF human hepatocellular carcinoma cells (IC50s = 17-70 µg/ml). Baicalein increases intracellular calcium levels by increasing release from the endoplasmic reticulum and via PKC-dependent calcium channels in the plasma membrane, leading to increases in reactive oxygen species (ROS), caspase-9 and -3 activation, and apoptosis in ZR-75-1 human breast cancer cells. Baicalein increases levels of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) in BV-2 microglia and primary microglia and decreases the level of 12- and 15-LO products. It also decreases symptoms of experimental autoimmune encephalomyelitis (EAE) in a mouse model of multiple sclerosis, when administered at a dose of 75 mg/kg per day.Formal Name: 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one. CAS Number: 491-67-8. Molecular Formula: C15H10O5. Formula Weight: 270.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 52 mg/ml, DMSO: 28 mg/ml, Ethanol: 1.3 mg/ml, PBS (7.2): <90 µg/ml. lambdamax: 216, 277, 324 nm. SMILES: OC1=CC2=C(C(C=C(C3=CC=CC=C3)O2)=O)C(O)=C1O. InChi Code: InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H. InChi Key: FXNFHKRTJBSTCS-UHFFFAOYSA-N.