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![Baicalein](https://www.biomol.com/media/image/b8/1a/7f/Cay70610-1_600x600.png)
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Baicalein is a flavonoid originally isolated from the roots of S. baicalensis that has diverse... more
Product information "Baicalein"
Baicalein is a flavonoid originally isolated from the roots of S. baicalensis that has diverse biological activities. It inhibits human platelet 12-lipoxygenase (12-LO) and human reticulocyte 15-LO-1 (IC50s = 0.64 and 1.6 µM, respectively) but is less potent at 15-LO-1 when the detergent Triton-X is present (IC50 = 38 µM). Baicalein inhibits lipid peroxidation, as assessed by production of thiobarbituric acid (TBARS, IC50 = 5 µM), and inhibits growth of Huh-7, KIM-1, and HLF human hepatocellular carcinoma cells (IC50s = 17-70 µg/ml). Baicalein increases intracellular calcium levels by increasing release from the endoplasmic reticulum and via PKC-dependent calcium channels in the plasma membrane, leading to increases in reactive oxygen species (ROS), caspase-9 and -3 activation, and apoptosis in ZR-75-1 human breast cancer cells. Baicalein increases levels of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) in BV-2 microglia and primary microglia and decreases the level of 12- and 15-LO products. It also decreases symptoms of experimental autoimmune encephalomyelitis (EAE) in a mouse model of multiple sclerosis, when administered at a dose of 75 mg/kg per day.Formal Name: 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one. CAS Number: 491-67-8. Molecular Formula: C15H10O5. Formula Weight: 270.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 52 mg/ml, DMSO: 28 mg/ml, Ethanol: 1.3 mg/ml, PBS (7.2): <90 µg/ml. lambdamax: 216, 277, 324 nm. SMILES: OC1=CC2=C(C(C=C(C3=CC=CC=C3)O2)=O)C(O)=C1O. InChi Code: InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H. InChi Key: FXNFHKRTJBSTCS-UHFFFAOYSA-N.
Keywords: | 5,6,7-trihydroxyflavone |
Supplier: | Cayman Chemical |
Supplier-Nr: | 70610 |
Properties
Application: | Lipid peroxidation inhibitor |
MW: | 270.2 D |
Formula: | C15H10O5 |
Purity: | >95% |
Format: | Crystalline Solid |
Database Information
CAS : | 491-67-8| Matching products |
KEGG ID : | K00458 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H315, H319, H335 |
P Phrases: | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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