(±)-Baclofen-d4

(±)-Baclofen-d4 is intended for use as an internal standard for the quantification of (±)-baclofen (Cay-18600) by GC- or LC-MS. (±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM). It induces norepinephrine release from isolated rat atria (IC50 = 4.5 µM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice. It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats. (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice. Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.Formal Name: 4-amino-3-(4-chlorophenyl-2,3,5,6-d4)butanoic acid. CAS Number: 1189938-30-4. Molecular Formula: C10H8ClD4NO2. Formula Weight: 217.7. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: Water: soluble. SMILES: ClC1=C([2H])C([2H])=C(C(CN)CC(O)=O)C([2H])=C1[2H]. InChi Code: InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)/i1D,2D,3D,4D. InChi Key: KPYSYYIEGFHWSV-RHQRLBAQSA-N.