B-RAF IN 1

B-RAF IN 1 is an inhibitor of B-RAF (IC50 = 24 nM) that also inhibits C-RAF (IC50 = 25 nM). It is selective over 13 other kinases, including PKCalpha, IKKbeta, and PI3Kalpha, at concentrations greater than 2 µM, but does inhibit p38alpha and CAMKII (IC50s = 216 and 822 nM, respectively). B-RAF IN 1 binds to B-RAF in the inactive conformation based on co-crystallization with the wild-type enzyme. It inhibits proliferation of WM 266-4 and HT29 cells with IC50 values of 920 and 780 nM, respectively.Formal Name: N-[3-[3-[4-[(dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)-benzamide. CAS Number: 950736-05-7. Synonyms: B-RAF Inhibitor 1. Molecular Formula: C29H24F3N5O. Formula Weight: 515.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14 mg/ml, DMSO: 33 mg/ml, Ethanol: 1 mg/ml. lambdamax: 269 nm. SMILES: CN(C)CC(C=C1)=CC=C1C2=C3N=CC=C(C4=CC=CC(NC(C5=CC=CC(C(F)(F)F)=C5)=O)=C4)N3N=C2. InChi Code: InChI=1S/C29H24F3N5O/c1-36(2)18-19-9-11-20(12-10-19)25-17-34-37-26(13-14-33-27(25)37)21-5-4-8-24(16-21)35-28(38)22-6-3-7-23(15-22)29(30,31)32/h3-17H,18H2,1-2H3,(H,35,38). InChi Key: AIWJVLQNYNCDSL-UHFFFAOYSA-N.