B-HT 933 (hydrochloride)

B-HT 933 is an agonist of alpha2-adrenergic receptors (alpha2-ARs) with an EC50 value of 0.65 µM for contraction of canine sapheneous veins. It induces concentration-dependent inhibition of the twitch response in rat vas deferens and guinea pig ileum. B-HT 933 induces sedation and reduces motor activity in mice, an effect that is reversed by the alpha2-AR antagonist yohimbine (Cay-19869). B-HT 933 decreases blood pressure and cardiac output in cats injected with 30 µg/kg intracisternally. It also exhibits antinociceptive effects in mice with ED50 values of 12.5, 20.5, and 6.1 mg/kg for the tail-immersion, tail-pinch, and acetic acid writhing tests, respectively.Formal Name: 6-ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine, dihydrochloride. CAS Number: 36067-72-8. Synonyms: Azepexole, Oxazoloazepin. Molecular Formula: C9H15N3O . 2HCl. Formula Weight: 254.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 220 nm. SMILES: CCN1CCC(OC(N)=N2)=C2CC1.Cl.Cl. InChi Code: InChI=1S/C9H15N3O.2ClH/c1-2-12-5-3-7-8(4-6-12)13-9(10)11-7,,/h2-6H2,1H3,(H2,10,11),2*1H. InChi Key: HBLPYIOKPJVFQW-UHFFFAOYSA-N.