AZD 7648

AZD 7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK, IC50 = 0.63 nM in an enzyme assay). It is selective for DNA-PK over TTK (IC50 = 5.012 µM), as well as JAK1, JAK2, JAK3, Aurora A, and Aurora B (IC50s = >10 µM for all). AZD 7648 reduces tumor growth in a FaDu ATM KO pharynx cancer mouse xenograft model when administered at doses of 37.5 or 75 mg/kg twice per day and induces tumor regression at these doses when administered in combination with the PARP inhibitor olaparib (Cay-10621).Formal Name: 7,9-dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one. CAS Number: 2230820-11-6. Molecular Formula: C18H20N8O2. Formula Weight: 380.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 211, 263, 319 nm. SMILES: CN1C2=CN=C(NC3=CN4C(C=C3C)=NC=N4)N=C2N(C5CCOCC5)C1=O. InChi Code: InChI=1S/C18H20N8O2/c1-11-7-15-20-10-21-25(15)9-13(11)22-17-19-8-14-16(23-17)26(18(27)24(14)2)12-3-5-28-6-4-12/h7-10,12H,3-6H2,1-2H3,(H,19,22,23). InChi Key: XISVSTPEXYIKJL-UHFFFAOYSA-N.