AZD 5069

AZD 5069 is an antagonist of chemokine receptor 2 (CXCR2, IC50 = 0.79 nM in a radioligand binding assay). It inhibits CXCL1-induced CD11b expression in and chemotaxis of isolated human neutrophils (pA2s = 6.9 and 9.1, respectively). AZD 5069 (3 and 10 µmol/kg) inhibits bronchoalveolar lavage fluid (BALF) neutrophil influx in a rat model of LPS-induced lung neutrophilia and non-allergic airway inflammation.Formal Name: N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-[(1R,2S)-2,3-dihydroxy-1-methylpropoxy]-4-pyrimidinyl]-1-azetidinesulfonamide. CAS Number: 878385-84-3. Molecular Formula: C18H22F2N4O5S2. Formula Weight: 476.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 254 nm. SMILES: FC1=C(F)C(CSC2=NC(O[C@H](C)[C@@H](O)CO)=CC(NS(N3CCC3)(=O)=O)=N2)=CC=C1. InChi Code: InChI=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22-16)30-10-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2,1H3,(H,21,22,23)/t11-,14+/m1/s1. InChi Key: QZECRCLSIGFCIO-RISCZKNCSA-N.