AZD 3839

AZD 3839 is an inhibitor of beta-secretase 1 (BACE1). It selectively binds to BACE1 over BACE2 (Kis = 26.1 and 372.4 nM, respectively, for the human enzymes). It also inhibits human ether-a-go-go-related gene (hERG) potassium channels expressed in CHO cells (IC50 = 4.8 µM). AZD 3839 decreases amyloid-beta (Abeta) secretion from mouse Neuro2a neuroblastoma cells and primary neurons (IC50s = 32.2 and 50.9 nM, respectively). It dose- and time-dependently decreases Abeta levels in the plasma and brain of mice and guinea pigs. AZD 3839 also decreases Abeta in the cerebrospinal fluid (CSF) of cynomolgus monkeys when administered at a dose of 20 µmol/kg.Formal Name: (1S)-1-[2-(difluoromethyl)-4-pyridinyl]-4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-1H-isoindol-3-amine. CAS Number: 1227163-84-9. Molecular Formula: C24H16F3N5. Formula Weight: 431.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. SMILES: FC1=C(C(N)=N[C@@]2(C3=CC=CC(C4=CN=CN=C4)=C3)C5=CC(C(F)F)=NC=C5)C2=CC=C1. InChi Code: InChI=1S/C24H16F3N5/c25-19-6-2-5-18-21(19)23(28)32-24(18,17-7-8-31-20(10-17)22(26)27)16-4-1-3-14(9-16)15-11-29-13-30-12-15/h1-13,22H,(H2,28,32)/t24-/m0/s1. InChi Key: MRXBCEQZNKUUIP-DEOSSOPVSA-N.