AZD 3293

AZD 3293 is an inhibitor of beta-secretase 1 (BACE1) and BACE2 (Kis = 0.4 and 0.8 nM, respectively). It is selective for BACE1 and BACE2 over cathepsin D, gamma-secretase, and human-ether-a-go-go (hERG, IC50s = 3,797, >25,000, and 4,700 nM, respectively). AZD 3293 inhibits the secretion of amyloid-beta (1-40) (Abeta40) in primary mouse and guinea pig neuronal cultures (IC50s = 0.61 and 0.31 NM, respectively), as well as in SH-SY5Y cells overexpressing human amyloid precursor protein (APP, IC50 = 0.08 nM). In vivo, AZD 3293 (50, 100, and 200 µmol/kg) reduces plasma and brain levels of Abeta40 and brain levels of Abeta42 in mice.Formal Name: (1alpha,1'R,4beta)-4-methoxy-5''-methyl-6'-[5-(1-propyn-1-yl)-3-pyridinyl]-dispiro[cyclohexane-1,2'-[2H]indene-1'(3'H),2''-[2H]imidazol]-4''-amine. CAS Number: 1383982-64-6. Synonyms: Lanabecestat, LY3314814. Molecular Formula: C26H28N4O. Formula Weight: 412.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble. lambdamax: 241 nm. SMILES: CO[C@@H](CC1)CC[C@@]1(C2)[C@]3(N=C(C)C(N)=N3)C4=C2C=CC(C5=CC(C#CC)=CN=C5)=C4. InChi Code: InChI=1S/C26H28N4O/c1-4-5-18-12-21(16-28-15-18)19-6-7-20-14-25(10-8-22(31-3)9-11-25)26(23(20)13-19)29-17(2)24(27)30-26/h6-7,12-13,15-16,22H,8-11,14H2,1-3H3,(H2,27,30)/t22-,25-,26-/m0/s1. InChi Key: WKDNQONLGXOZRG-HRNNMHKYSA-N.