Azathioprine

Azathioprine is a purine analog with immunosuppressive effects. It serves as a prodrug for 6-mercaptopurine, which alters purine processing and DNA synthesis, interfering with the proliferation of lymphocytes and other myeloid cells. Its immunomodulating actions are used to benefit inflammatory bowel disease, as well as a wide range of additional diseases with immunological or autoimmunological components, including rheumatoid arthritis and lupus nephritis.Formal Name: 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine. CAS Number: 446-86-6. Synonyms: Azamune, Azoran, BW 57-322, Imuran, NSC 39084. Molecular Formula: C9H7N7O2S. Formula Weight: 277.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 12.5 mg/ml. lambdamax: 207, 276 nm. SMILES: CN1C(SC2=NC=NC3=C2NC=N3)=C([N+]([O-])=O)N=C1. InChi Code: InChI=1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13). InChi Key: LMEKQMALGUDUQG-UHFFFAOYSA-N.