Azatadine (maleate)

Azatadine (maleate)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay29758-50 50 mg -

6 - 10 business days*

83.00€
Cay29758-100 100 mg -

6 - 10 business days*

146.00€
Cay29758-250 250 mg -

6 - 10 business days*

260.00€
Cay29758-500 500 mg -

6 - 10 business days*

480.00€
 
Azatadine is an antihistamine with anticholinergic and antiserotonergic activities., It is a... more
Product information "Azatadine (maleate)"
Azatadine is an antihistamine with anticholinergic and antiserotonergic activities., It is a histamine H1 receptor antagonist (Ki = 3.9 nM)., Azatadine inhibits histamine- and acetylcholine-induced contractions in isolated guinea pig ilium and contractions induced by serotonin (5-HT, Cay-14332) in isolated rat uterus (EC50s = 6.5, 10, and 14 nM, respectively). It delays the onset of dyspnea induced by aerosolized histamine, 5-HT, or acetylcholine in guinea pigs. Azatadine prevents histamine-induced lethality in guinea pigs and paw edema in mice (ED50s = 9 and 68 µg/kg, respectively). It increases survival in guinea pig and mouse models of anaphylactic shock with 50% protective dose (PD50) values of 0.024 and 0.019 mg/kg, respectively.Formal Name: 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, (2Z)-2-butenedioate. CAS Number: 3978-86-7. Molecular Formula: C20H22N2 . 2C4H4O4. Formula Weight: 522.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20mg/mL, DMSO: 20mg/mL, Ethanol: 5mg/mL, PBS (pH 7.2): 10mg/mL. SMILES: CN(CC/1)CCC1=C2C(N=CC=C3)=C3CCC4=C\2C=CC=C4.OC(/C=C\C(O)=O)=O.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C20H22N2.2C4H4O4/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19,2*5-3(6)1-2-4(7)8/h2-7,12H,8-11,13-14H2,1H3,2*1-2H,(H,5,6)(H,7,8)/b,2*2-1-. InChi Key: SGHXFFAHXTZRQM-SPIKMXEPSA-N.
Keywords: 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, (2Z)-2-butenedioate
Supplier: Cayman Chemical
Supplier-Nr: 29758

Properties

Application: Histamine receptor H1 antagonist
MW: 522.6 D
Formula: C20H22N2 . 2C4H4O4
Purity: >98%
Format: Solid

Database Information

CAS : 3978-86-7| Matching products
KEGG ID : K04149 | Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H312, H317, H319, H332
P Phrases: P261, P264, P270, P271, P272, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P333+P313, P337+P313, P361+P364, P362+P364, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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