Azacyclonol

Azacyclonol is a CNS depressant. It reduces transmission through the sympathetic ganglia, decreasing electrically stimulated contractile responses in feline nictitating membrane. It reduces coordinated locomotor activity in mice by greater than 50% when administered at doses of 71, 142, and 213 mg/kg. Azacyclonol (142 mg/kg) decreases hyperactivity induced by pipradol, D-amphetamine, morphine, and cocaine. It also increases the duration of sleeping time induced by hexobarbital. Azacyclonol is also a metabolite of the histamine H1 receptor antagonist terfenadine (Cay-20305). It is formed from terfenadine by the cytochrome P450 (CYP) isoform CYP3A4.Formal Name: alpha,alpha-diphenyl-4-piperidinemethanol. CAS Number: 115-46-8. Synonyms: MDL 4829, MER 17, gamma-Pipradol. Molecular Formula: C18H21NO. Formula Weight: 267.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml. lambdamax: 262 nm. SMILES: OC(C1=CC=CC=C1)(C2=CC=CC=C2)C3CCNCC3. InChi Code: InChI=1S/C18H21NO/c20-18(15-7-3-1-4-8-15,16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-10,17,19-20H,11-14H2. InChi Key: ZMISODWVFHHWNR-UHFFFAOYSA-N.