AZ-GHS-22

Description: AZ-GHS-22 is an inverse agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor.1It binds to GHS-R1a with an IC50value of 0.77 nM. AZ-GHS-22 decreases food intake in mice by 54% in the first two hours after administration of a 100 mg/kg dose. Target: Others. Smiles: N(C(NC(=O)C1=CC(=CC=C1Cl)N2CCOCC2)=O)C=3SC=4C(N3)=CC=C(S(CCCN5CCN(C)CC5)(=O)=O)C4. References: McCoull, W., Barton, P., Brown, A.J.H., et al.Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonistsJ. Med. Chem.57(14)6128-6140(2014)