AZ-GHS-22

AZ-GHS-22 is an inverse agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor. It binds to GHS-R1a with an IC50 value of 0.77 nM. AZ-GHS-22 decreases food intake in mice by 54% in the first two hours after administration of a 100 mg/kg dose.Formal Name: 2-chloro-N-[[[6-[[3-(4-methyl-1-piperazinyl)propyl]sulfonyl]-2-benzothiazolyl]amino]carbonyl]-5-(4-morpholinyl)-benzamide. CAS Number: 1143020-91-0. Molecular Formula: C27H33ClN6O5S2. Formula Weight: 621.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: 0.1 M HCl: 25 mg/ml, DMSO: 50 mg/ml. SMILES: O=C(NC1=NC2=C(S1)C=C(S(=O)(CCCN3CCN(CC3)C)=O)C=C2)NC(C4=CC(N5CCOCC5)=CC=C4Cl)=O. InChi Code: InChI=1S/C27H33ClN6O5S2/c1-32-8-10-33(11-9-32)7-2-16-41(37,38)20-4-6-23-24(18-20)40-27(29-23)31-26(36)30-25(35)21-17-19(3-5-22(21)28)34-12-14-39-15-13-34/h3-6,17-18H,2,7-16H2,1H3,(H2,29,30,31,35,36). InChi Key: XWFQFKFKWKWIEW-UHFFFAOYSA-N.