AZ 32

AZ 32 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase (IC50 = 50s = 4.6 and >4.6 µM, respectively). AZ 32 enhances radiation-induced cytotoxicity in a panel of five human glioma cells expressing wild-type or mutant p53. It increases survival in a U87-281G glioma orthotopic mouse xenograft model, as well as a NCI H2228 non-small cell lung cancer (NSCLC) mouse xenograft model of metastatic brain tumors, when administered at doses of 200 and 50 mg/kg, respectively, in combination with ionizing radiation.Formal Name: N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)-benzamide. CAS Number: 2288709-96-4. Molecular Formula: C20H16N4O. Formula Weight: 328.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 150 mg/ml. SMILES: O=C(NC)C1=CC=C(C2=CN=C3N2C=C(C4=CC=CC=C4)N=C3)C=C1. InChi Code: InChI=1S/C20H16N4O/c1-21-20(25)16-9-7-15(8-10-16)18-11-23-19-12-22-17(13-24(18)19)14-5-3-2-4-6-14/h2-13H,1H3,(H,21,25). InChi Key: LCRTUEXVVKVKBD-UHFFFAOYSA-N.