AY 9944
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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: AY 9944 is a specific cholesterol biosynthesis inhibitor that targets the... more
Product information "AY 9944"
Description: AY 9944 is a specific cholesterol biosynthesis inhibitor that targets the 7-dehydrocholesterol Delta7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 also inhibits sterol Delta7-Delta8 isomerase in cultured embryos, leading to the accumulation of cholest-8-en-3beta-ol[1][2][3]. Additionally, AY 9944 causes hypocholesterolemia and accumulation of 7DHC. Target: Others. Smiles: Cl.Cl.Clc1ccccc1CNC[C@H]1CC[C@H](CNCc2ccccc2Cl)CC1. References: Dvornik D, et al. Effect of long-term administration of AY-9944, an inhibitor of 7-dehydrocholesterol delta 7-reductase, on serum and tissue lipids in the rat. J Lipid Res. 1968 Sep,9(5):587-95.
| Supplier: | TargetMol |
| Supplier-Nr: | T14362 |
Properties
| Application: | DHCR7 inhibitor |
| MW: | 464.3 D |
| Formula: | C22H30Cl4N2 |
Database Information
| CAS : | 366-93-8| Matching products |
| KEGG ID : | K00213 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301, H315, H319, H335, H410 |
| P Phrases: | P261, P264, P270, P271, P273, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P391, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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